Sarcoidosis – a clinically orientated review
Identifieur interne : 001169 ( Main/Exploration ); précédent : 001168; suivant : 001170Sarcoidosis – a clinically orientated review
Auteurs : Mahmoud Dastoori [Royaume-Uni] ; Stefano Fedele [Royaume-Uni] ; Jair C. Leao [Royaume-Uni, Brésil] ; Stephen R. Porter [Royaume-Uni]Source :
- Journal of Oral Pathology & Medicine [ 0904-2512 ] ; 2013-04.
English descriptors
- Teeft :
- Asymptomatic, Baughman, Cardiac, Chloroquine, Clin, Corticosteroid, Crit, Cutaneous, Dastoori, Epidemiology, Erythema nodosum, Granuloma, Granulomatous, Hepatic, Hepatic sarcoidosis, Macrophage, Neopterin, Nodule, Ocular sarcoidosis, Oral pathol, Orientated, Orientated review dastoori, Pathol, Pulmonary sarcoidosis, Respir, Respir crit care, Sarcoid, Sarcoidosis, Sarcoidosis vasc, Vasc.
Abstract
Sarcoidosis is a multisystem disease of unknown cause. Sarcoidosis can affect all individuals with any race, sex, or age but commonly affects young‐ and middle‐aged adults and usually presents with bilateral hilar lymphadenopathy, pulmonary infiltration, skin and ocular lesions. Other organs can also be affected. Diagnosis is established when clinical and radiological findings are supported by the presence of non‐caseating epithelioid cell granulomas, however, local sarcoid reactions and granulomas of known cause should be excluded. The optimal management has not been well defined yet, although corticosteroids remain the mainstay of treatment, there is little evidence on which to base the indications for treatment including dosage and duration of therapy. Certain clinical features are helpful in the prognosis of the condition that can vary from a self‐limiting course to progressive life‐threatening fibrosis of the vital organs.
Url:
DOI: 10.1111/j.1600-0714.2012.01198.x
Affiliations:
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Porter</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Maxillofacial Medicine and Surgery, Oral Medicine unit, UCL Eastman Dental Institute, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Oral Pathology & Medicine</title><title level="j" type="alt">JOURNAL OF ORAL PATHOLOGY AND MEDICINE</title><idno type="ISSN">0904-2512</idno><idno type="eISSN">1600-0714</idno><imprint><biblScope unit="vol">42</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="281">281</biblScope><biblScope unit="page" to="289">289</biblScope><biblScope unit="page-count">9</biblScope><date type="published" when="2013-04">2013-04</date></imprint><idno type="ISSN">0904-2512</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0904-2512</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Asymptomatic</term><term>Baughman</term><term>Cardiac</term><term>Chloroquine</term><term>Clin</term><term>Corticosteroid</term><term>Crit</term><term>Cutaneous</term><term>Dastoori</term><term>Epidemiology</term><term>Erythema nodosum</term><term>Granuloma</term><term>Granulomatous</term><term>Hepatic</term><term>Hepatic sarcoidosis</term><term>Macrophage</term><term>Neopterin</term><term>Nodule</term><term>Ocular sarcoidosis</term><term>Oral pathol</term><term>Orientated</term><term>Orientated review dastoori</term><term>Pathol</term><term>Pulmonary sarcoidosis</term><term>Respir</term><term>Respir crit care</term><term>Sarcoid</term><term>Sarcoidosis</term><term>Sarcoidosis vasc</term><term>Vasc</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Sarcoidosis is a multisystem disease of unknown cause. Sarcoidosis can affect all individuals with any race, sex, or age but commonly affects young‐ and middle‐aged adults and usually presents with bilateral hilar lymphadenopathy, pulmonary infiltration, skin and ocular lesions. Other organs can also be affected. Diagnosis is established when clinical and radiological findings are supported by the presence of non‐caseating epithelioid cell granulomas, however, local sarcoid reactions and granulomas of known cause should be excluded. The optimal management has not been well defined yet, although corticosteroids remain the mainstay of treatment, there is little evidence on which to base the indications for treatment including dosage and duration of therapy. Certain clinical features are helpful in the prognosis of the condition that can vary from a self‐limiting course to progressive life‐threatening fibrosis of the vital organs.</div></front></TEI><affiliations><list><country><li>Brésil</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Dastoori, Mahmoud" sort="Dastoori, Mahmoud" uniqKey="Dastoori M" first="Mahmoud" last="Dastoori">Mahmoud Dastoori</name></region><name sortKey="Fedele, Stefano" sort="Fedele, Stefano" uniqKey="Fedele S" first="Stefano" last="Fedele">Stefano Fedele</name><name sortKey="Leao, Jair C" sort="Leao, Jair C" uniqKey="Leao J" first="Jair C." last="Leao">Jair C. Leao</name><name sortKey="Porter, Stephen R" sort="Porter, Stephen R" uniqKey="Porter S" first="Stephen R." last="Porter">Stephen R. 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